![]() ![]() This has a number of benefits, the most obvious of which is that it is far more effecient than attempting to build a genome from scratch. These assemblies provide a powerful shortcut when mapping reads as they can be mapped to the assembly, rather than each other, to piece the genome of a new individual together. A reference assembly is a complete (as much as possible) representation of the nucleotide sequence of a representative genome for a specific species. Download this firstįirst let’s go over what a reference assembly actually is. This post is inspired by this BioStars post (also created by the authors of this workshop). In this section we will go over a few tools to perform this type of analysis, in many cases these tools can be used interchangeably. Many resources exist for performing this and other related tasks. For example, you have a bed file with exon coordinates for human build GRC37 (hg19) and wish to update to GRCh38. Probably the most common situation is that you have some coordinates for a particular version of a reference genome and you want to determine the corresponding coordinates on a different version of the reference genome for that species. « Introduction to BioMart Course Introduction to ProteinPaint »Ī common analysis task is to convert genomic coordinates between different assemblies. ![]()
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